Diabetes Mellitus as a primary manifestation of Multiple Endocrine Neoplasia Type 2BI

Wed, 11/02/2009 - 13:40 — Luc Michel
published in Acta Chirurgica
2008; 108:732-737

Abstract

A 22-year-old-man presenting with diabetes mellitus was found to suffer from multiple endocrine neoplasia type 2B (MEN B). The characteristic phenotype including mucosal neuromas, musculoskeletal abnormalities and a marfanoid habitus led us to suspect this diagnosis, which was confirmed by the genetic analysis showing the typical mutation in the RET proto-oncogene at codon 918. Subsequently, diagnoses of bilateral phaeochromocytoma and medullary thyroid carcinoma were made. The patient underwent first a laparoscopic removal of bilateral phaeochromocytoma and a radical thyroidectomy three months later. Both operations were uneventful. After operation, diabetes resolved, an effect partly explainable by an improvement of insulin sensitivity. Thus, clinicians should be aware of a diagnosis of MEN 2B in a young patient presenting with diabetes, a typical phenotype, symptoms of phaeochromocytoma or a nodule in the thyroid.

Published under a Creative Commons License: By attribution, non-commercial, share like.
5
Your rating: None Average: 5 (1 vote)


Warning: INSERT command denied to user 'dbo272419331'@'212.227.24.38' for table 'drupal_watchdog' query: INSERT INTO drupal_watchdog (uid, type, message, variables, severity, link, location, referer, hostname, timestamp) VALUES (0, 'php', '%message in %file on line %line.', 'a:4:{s:6:\"%error\";s:12:\"user warning\";s:8:\"%message\";s:446:\"INSERT command denied to user 'dbo272419331'@'212.227.24.38' for table 'drupal_accesslog'\nquery: INSERT INTO drupal_accesslog (title, path, url, hostname, uid, sid, timer, timestamp) values('Diabetes Mellitus as a primary manifestation of Multiple Endocrine Neoplasia Type 2BI', 'node/259', '', '54.224.2.123', 0, '7d3f3259f5a05c0e3a715d899416cd8f', 122, 1532138568)\";s:5:\"%file\";s:67:\"/homepages/1/d154244742/htdocs/mo in /homepages/1/d154244742/htdocs/includes/database.mysqli.inc on line 128